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2009 1
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Page 1
Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene.
Liquori A, Ibañez M, Sargas C, Sanz MÁ, Barragán E, Cervera J. Liquori A, et al. Cancers (Basel). 2020 Mar 8;12(3):624. doi: 10.3390/cancers12030624. Cancers (Basel). 2020. PMID: 32182684 Free PMC article. Review.
However, the gene expression profile of genes, such as ID1, BAALC, ERG, and KMT2E, once combined with the molecular events, might improve future prognostic models, allowing us to predict clinical outcomes and to categorize APL patients in different risk subsets, as recentl …
However, the gene expression profile of genes, such as ID1, BAALC, ERG, and KMT2E, once combined with the molecular events, might imp …
Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
Tai YY, Yu Q, Tang Y, Sun W, Kelly NJ, Okawa S, Zhao J, Schwantes-An TH, Lacoux C, Torrino S, Al Aaraj Y, El Khoury W, Negi V, Liu M, Corey CG, Belmonte F, Vargas SO, Schwartz B, Bhat B, Chau BN, Karnes JH, Satoh T, Barndt RJ, Wu H, Parikh VN, Wang J, Zhang Y, McNamara D, Li G, Speyer G, Wang B, Shiva S, Kaufman B, Kim S, Gomez D, Mari B, Cho MH, Boueiz A, Pauciulo MW, Southgate L, Trembath RC, Sitbon O, Humbert M, Graf S, Morrell NW, Rhodes CJ, Wilkins MR, Nouraie M, Nichols WC, Desai AA, Bertero T, Chan SY. Tai YY, et al. Sci Transl Med. 2024 Jan 10;16(729):eadd2029. doi: 10.1126/scitranslmed.add2029. Epub 2024 Jan 10. Sci Transl Med. 2024. PMID: 38198571 Free PMC article.
In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)-dependent vascular dysfunction, HIF-2alpha promoted expression of neighboring genes, long noncoding RNA (lncRNA) histone lysine N-methyltransferase 2E-antisense 1 (KMT2E-AS1) and h …
In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)-dependent vascular dysfunction, HIF-2alpha prom …
Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths.
Spindola LM, Santoro ML, Pan PM, Ota VK, Xavier G, Carvalho CM, Talarico F, Sleiman P, March M, Pellegrino R, Brietzke E, Grassi-Oliveira R, Mari JJ, Gadelha A, Miguel EC, Rohde LA, Bressan RA, Mazzotti DR, Sato JR, Salum GA, Hakonarson H, Belangero SI. Spindola LM, et al. Clin Epigenetics. 2019 Oct 21;11(1):146. doi: 10.1186/s13148-019-0740-z. Clin Epigenetics. 2019. PMID: 31639064 Free PMC article.
The DNA methylation and gene expression data were compared in peripheral blood samples (n = 48) obtained from the 24 youths before and after developing psychopathology. ...We observed that 15 DMPs were mapped to genes that were differentially expressed in the blood; …
The DNA methylation and gene expression data were compared in peripheral blood samples (n = 48) obtained from the 24 youths before an …
DNA Methyltransferase 1 Targeting Using Guadecitabine Inhibits Prostate Cancer Growth by an Apoptosis-Independent Pathway.
Karan D, Singh M, Dubey S, Van Veldhuizen PJ, Saunthararajah Y. Karan D, et al. Cancers (Basel). 2023 May 15;15(10):2763. doi: 10.3390/cancers15102763. Cancers (Basel). 2023. PMID: 37345101 Free PMC article.
In further investigating the mechanism of cytoreduction by gDEC, a PCR array analyses of 84 chromatin modifying enzymes demonstrated upregulation of several lysine-specific methyltransferases (KMTs: KMT2A, KMT2C, KMT2E, KMT2H, KMT5A), confirmed by additional expression ana …
In further investigating the mechanism of cytoreduction by gDEC, a PCR array analyses of 84 chromatin modifying enzymes demonstrated upregul …
Comprehensive genomic analysis reveals molecular heterogeneity in pediatric ALK-positive anaplastic large cell lymphoma.
Shaw TI, Pounds S, Cao X, Ma J, Palacios G, Mason J, Perkins S, Wu G, Fan Y, Wang J, Zhou X, Obermayer A, Kinney MC, Kraveka J, Gross T, Sandlund J, Zhang J, Mullighan C, Lim MS, Leventaki V. Shaw TI, et al. Res Sq [Preprint]. 2024 Mar 28:rs.3.rs-4145750. doi: 10.21203/rs.3.rs-4145750/v1. Res Sq. 2024. PMID: 38585847 Free PMC article. Preprint.
Whole-exome sequencing found on average 25 SNV/Indel events per sample with recurring genetic events in regulators of DNA damage (TP53, MDM4), transcription (JUNB), and epigenetic regulators (TET1, KMT2B, KMT2A, KMT2C, KMT2E). Gene expression and methylation profiling cons …
Whole-exome sequencing found on average 25 SNV/Indel events per sample with recurring genetic events in regulators of DNA damage (TP53, MDM4 …
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data.
D'Cruz SC, Hao C, Labussiere M, Mustieles V, Freire C, Legoff L, Magnaghi-Jaulin L, Olivas-Martinez A, Rodriguez-Carrillo A, Jaulin C, David A, Fernandez MF, Smagulova F. D'Cruz SC, et al. Clin Epigenetics. 2022 Dec 26;14(1):186. doi: 10.1186/s13148-022-01408-2. Clin Epigenetics. 2022. PMID: 36572933 Free PMC article.
Results were supported in HeLa cells exposed to 10 nM BPA in vitro. In accordance with the data obtained in blood samples, we observed higher H3K4me3 occupancy and lower DNA methylation at some specific targets in HeLa cells. ...Furthermore, an increase in ESR1/ERa was obs …
Results were supported in HeLa cells exposed to 10 nM BPA in vitro. In accordance with the data obtained in blood samples, we observe …
Single-Cell RNA Sequencing Analysis of the Immunometabolic Rewiring and Immunopathogenesis of Coronavirus Disease 2019.
Qi F, Zhang W, Huang J, Fu L, Zhao J. Qi F, et al. Front Immunol. 2021 Apr 14;12:651656. doi: 10.3389/fimmu.2021.651656. eCollection 2021. Front Immunol. 2021. PMID: 33936072 Free PMC article.
Here, by reanalyzing single-cell RNA sequencing data, we delineated metabolic remodeling in peripheral blood mononuclear cells (PBMCs) to elucidate the metabolic mechanisms that may lead to the progression of severe COVID-19. ...The mono-CD16(+) cell population in COVID-19 …
Here, by reanalyzing single-cell RNA sequencing data, we delineated metabolic remodeling in peripheral blood mononuclear cells (PBMCs …
ALKBH5 inhibitors as a potential treatment strategy in heart failure-inferences from gene expression profiling.
Komal S, Gohar A, Althobaiti S, Ahmad Khan I, Cui LG, Zhang LR, Han SN, Shakeel M. Komal S, et al. Front Cardiovasc Med. 2023 Jul 31;10:1194311. doi: 10.3389/fcvm.2023.1194311. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37583580 Free PMC article.
Heart Failure (HF) is a complex clinical syndrome in which the heart is unable to provide enough blood flow to meet metabolic needs and lacks efficient venous return. ...The analyses revealed novel gene-markers including ALKBH5 of mRNA demethylation and KMT2E of his …
Heart Failure (HF) is a complex clinical syndrome in which the heart is unable to provide enough blood flow to meet metabolic needs a …
20 results